PIAS4 and HNRNPUL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PIAS4	HNRNPUL1
Description		protein inhibitor of activated STAT 4	heterogeneous nuclear ribonucleoprotein U like 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex	Nucleus Nucleoplasm Synapse Ribonucleoprotein Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity	RNA Binding Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Alternative MRNA Splicing, Via Spliceosome RNA Processing Response To Virus
Pathways		Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10	56 interacting genes: BRD7 CEBPA CRMP1 DMRTB1 DZIP3 EP300 ERG ERG28 EWSR1 FOXP1 FXR1 GIT2 HNRNPF HNRNPH2 HNRNPH3 IL7R ITCH KLHDC7B MAPK1IP1L MARS1 MED31 NEDD4 NXF1 NXF2 NXF3 PIAS2 PIAS4 PPIL1 PPP1R13B PRMT1 PRMT2 PRPF40A PTEN RBM22 RBM4 RBM4B ROPN1 RPA1 RPA2 SF1 SF3B4 SMN1 SMN2 SNRPB2 SNRPC SORBS3 SRSF9 TGM2 TLX3 TMEM132D TP53 TP53BP2 VPS37C WWP2 YAP1 ZNF207
Entrez ID		51588	11100
HPRD ID		06910	10428
Ensembl ID		ENSG00000105229	ENSG00000105323
Uniprot IDs		B3KMR4 Q8N2W9	A0A0A0MRA5 A8K3W4 B7Z4B8 Q9BUJ2
PDB IDs			1ZRJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process	Nucleoplasm RNA Splicing Nucleus Nucleic Acid Binding RNA Binding MRNA Processing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing Spliceosomal Complex Macromolecule Metabolic Process Spliceosomal Complex Assembly Nuclear RNA Export Factor Complex PML Body Negative Regulation Of Cell Cycle Regulation Of RNA Splicing Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition P53 Binding Transcription Coregulator Activity Protein-RNA Complex Assembly Regulation Of Androgen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition MRNA Binding MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin U1 SnRNP Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Poly(A)+ MRNA Export From Nucleus Cajal Body Regulation Of Cell Development Negative Regulation Of Mitotic Cell Cycle Nuclear Matrix Circadian Rhythm Regulation Of Macromolecule Metabolic Process Nuclear Androgen Receptor Binding
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