PIAS4 and CLK1

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIAS4	CLK1
Gene Name		protein inhibitor of activated STAT, 4	CDC-like kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Cell Proliferation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs			Debromohymenialdisine ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B	20 interactors: BCLAF1 GOLM1 KRTAP10-7 LUC7L3 MBP NCOR1 PDE9A PIAS4 PPIG PRMT5 PRPF4 PTPN1 SAFB SRPK1 SRPK2 SRSF1 SRSF3 SRSF6 UBL5 YWHAG
Entrez ID		51588	1195
HPRD ID		06910	09058
Ensembl ID			ENSG00000013441
Uniprot IDs		Q8N2W9	P49759
PDB IDs			1Z57 2VAG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death	RNA Splicing MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecular Complex Assembly Nuclear Export MRNA Transport Nucleus Organization Positive Regulation Of Viral Genome Replication RNA Transport Transcription, DNA-templated RNA Localization RNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Viral Genome Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Response To DNA Damage Stimulus Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Viral Genome Replication
Tagcloud ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq
Tagcloud (Difference) ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq
Tagcloud (Intersection) ?