UBE2J1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2J1	TRIM63
Gene Name		ubiquitin-conjugating enzyme E2, J1	tripartite motif containing 63, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BIRC2 BRCA1 DIO2 LRSAM1 MAPKAPK2 PARK2 PJA2 RNF2 SOX6 SYVN1 TOPORS TP53 TRIM27 TRIM63 UBA1	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		51465	84676
HPRD ID		15599	05843
Ensembl ID		ENSG00000198833	ENSG00000158022
Uniprot IDs		Q9Y385	B4DN95 Q969Q1
PDB IDs			2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Protein Monoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitochondrion Degradation Protein K6-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Organelle Organization Cellular Response To DNA Damage Stimulus DNA Damage Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?