UBE2J1 and PROKR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBE2J1	PROKR2
Description		ubiquitin conjugating enzyme E2 J1	prokineticin receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Spermatid Development Regulation Of Macrophage Cytokine Production Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Regulation Of Tumor Necrosis Factor Production ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Circadian Rhythm Cellular Response To Hormone Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS			Leukocyte telomere length ( 32109421)
Interacting Genes		50 interacting genes: AQP2 AQP6 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 SLC33A2 SLC71A2 SYVN1 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC UBR5	5 interacting genes: ADIPOQ FNDC9 GJA8 IGFBP5 UBE2J1
Entrez ID		51465	128674
HPRD ID		15599	08453
Ensembl ID		ENSG00000198833	ENSG00000101292
Uniprot IDs		Q9Y385	A8K1T0 Q8NFJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Endoplasmic Reticulum Membrane Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Protein Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Renal Water Transport Protein K48-linked Ubiquitination Transferase Activity Ubiquitin Ligase Complex Negative Regulation Of Response To Endoplasmic Reticulum Stress Protein K29-linked Ubiquitination Protein Modification Process	Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Migration Cellular Response To CAMP Negative Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Intracellular Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Response To Purine-containing Compound Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Insulin-like Growth Factor Ternary Complex Negative Regulation Of Protein Autophosphorylation Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Regulation Of Cholesterol Import Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Response To Sucrose Response To Disaccharide Hrd1p Ubiquitin Ligase Complex Insulin-like Growth Factor II Binding Negative Regulation Of Macrophage Differentiation Adiponectin-activated Signaling Pathway Regulation Of Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Intercellular Transport Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Exit From Endoplasmic Reticulum
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