UBE2J1 and DIO2

Number of citations of the paper that reports this interaction (PMID 12933904)
15

Data Source:
BioGRID (pull down)

		UBE2J1	DIO2
Gene Name		ubiquitin-conjugating enzyme E2, J1	deiodinase, iodothyronine, type II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BIRC2 BRCA1 DIO2 LRSAM1 MAPKAPK2 PARK2 PJA2 RNF2 SOX6 SYVN1 TOPORS TP53 TRIM27 TRIM63 UBA1	6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		51465	1734
HPRD ID		15599	09027
Ensembl ID		ENSG00000198833	ENSG00000211448
Uniprot IDs		Q9Y385	A8K845 Q92813 Q9HCP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Protein Monoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitochondrion Degradation Protein K6-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Organelle Organization Cellular Response To DNA Damage Stimulus DNA Damage Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding
Tagcloud ?		compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural	cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Difference) ?		compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural	cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Intersection) ?