UBE2J1 and UBA1

Number of citations of the paper that reports this interaction (PMID 17597759)
66

Data Source:
BioGRID (pull down)

		UBE2J1	UBA1
Gene Name		ubiquitin-conjugating enzyme E2, J1	ubiquitin-like modifier activating enzyme 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Heterochromatin Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Modification-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BIRC2 BRCA1 DIO2 LRSAM1 MAPKAPK2 PARK2 PJA2 RNF2 SOX6 SYVN1 TOPORS TP53 TRIM27 TRIM63 UBA1	39 interactors: BUB3 CDC34 CDK1 CREB3L1 CREB3L2 ECHS1 GAN GRB2 HGS HSPH1 MGMT PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2K UBE2L3 UBE2R2 UBE2S UBE2T UBE2W UBTD2
Entrez ID		51465	7317
HPRD ID		15599	02440
Ensembl ID		ENSG00000198833	ENSG00000130985
Uniprot IDs		Q9Y385	P22314
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Protein Monoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitochondrion Degradation Protein K6-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Organelle Organization Cellular Response To DNA Damage Stimulus DNA Damage Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteolysis Catabolic Process Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Protein Monoubiquitination Cellular Response To Stress Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Response To Organic Substance Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 3 Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Spindle Assembly Checkpoint
Tagcloud ?		compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Difference) ?		compromising conjugating cytosol destined dislocated dislocation elongate elongating fail incomplete lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitylated ultrastructural	aspect bax box caspases consisting counterpart debcl degrading documented drosophila fruitfly homologue iaps identifies involve modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp
Tagcloud (Intersection) ?		e3 ligase ubiquitin