FIS1 and A2M

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		FIS1	A2M
Gene Name		fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	alpha-2-macroglobulin
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Membrane Integral Component Of Mitochondrial Outer Membrane Protein Complex	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Receptor Binding Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Mitochondrial Fission Mitochondrion Degradation Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M BCAP31 CCDC155 DNM1L MARCH5 NOS3 PEX5 TBC1D15 UBC VKORC1	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		51024	2
HPRD ID		12352	00072
Ensembl ID		ENSG00000214253	ENSG00000175899
Uniprot IDs		Q9Y3D6	P01023
PDB IDs		1NZN 1PC2	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Fission Cellular Localization Regulation Of Mitochondrial Fission Protein Localization To Organelle Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Protein Localization To Mitochondrion Execution Phase Of Apoptosis Chromosome Localization To Nuclear Envelope Involved In Synapsis Mitochondrial Membrane Fission Dynamin Polymerization Involved In Mitochondrial Fission Oogenesis Mitochondrion Organization Blood Coagulation Regulation Of Signaling Hemostasis Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Negative Regulation Of Protein Homotetramerization Smooth Muscle Hyperplasia Negative Regulation Of Complement Activation, Lectin Pathway Protein Tetramerization Female Gamete Generation Spermatogenesis Male Gamete Generation Regulation Of Peroxisome Organization Protein Import Into Peroxisome Matrix, Translocation Regulation Of Body Fluid Levels Second-messenger-mediated Signaling Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Cellular Protein Localization Smooth Muscle Adaptation Protein Import Into Peroxisome Matrix, Docking Wound Healing Positive Regulation Of Cell Death Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Intrinsic Apoptotic Signaling Pathway Gamete Generation Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Protein Polyubiquitination Regulation Of Proteolysis	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?