A2M and STAMBPL1

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		A2M	STAMBPL1
Gene Name		alpha-2-macroglobulin	STAM binding protein-like 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Proteolysis
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs		Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	21 interactors: A2M CDC37 CEP72 ECSIT GNPTAB GOLGA2 IKZF3 INCA1 LAX1 MAGEA6 MAST1 PNMA1 PSEN1 RAB2A RNF11 RNF32 SMAD2 SMAD7 TCF4 TRIM27 TRIP13
Entrez ID		2	57559
HPRD ID		00072	16486
Ensembl ID		ENSG00000175899	ENSG00000138134
Uniprot IDs		P01023	Q96FJ0
PDB IDs		1BV8 2P9R 4ACQ	2ZNR 2ZNV
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Cellular Localization Protein Localization Establishment Of Localization In Cell Secretion By Cell Protein Secretion Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Protein Transport Secretion Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Negative Regulation Of Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of BMP Signaling Pathway Regulation Of Binding Negative Regulation Of Protein Metabolic Process Cellular Protein Complex Localization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Complex Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Post-embryonic Development Mesoderm Development Regulation Of Protein Metabolic Process Regulation Of Protein Binding Regulation Of Protein Kinase Activity Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Morphogenesis Cellular Component Assembly Regulation Of Immune Response Cell Cycle Cellular Protein Localization Negative Regulation Of BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Stem Cell Differentiation
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?