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A2M and MLST8
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
A2M
MLST8
Description
alpha-2-macroglobulin
MTOR associated protein MLST8
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Membrane
TORC1 Complex
TORC2 Complex
Serine/threonine Protein Kinase Complex
Molecular Function
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Peptidase Inhibitor Activity
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Stem Cell Differentiation
DNA Damage Response
Cytoskeleton Organization
Negative Regulation Of Autophagy
Positive Regulation Of Cell Growth
Positive Regulation Of Actin Filament Polymerization
Cellular Response To Nutrient Levels
TOR Signaling
Positive Regulation Of TOR Signaling
Regulation Of Actin Cytoskeleton Organization
TORC1 Signaling
TORC2 Signaling
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Glycolytic Process
Positive Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Hypoxia
Cellular Response To Osmotic Stress
Positive Regulation Of Pentose-phosphate Shunt
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
HDL assembly
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Refractive error (
32231278
)
Height (
28552196
)
Interacting Genes
99 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSP90AA1
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SLC6A4
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
USP40
13 interacting genes:
A2M
APPL2
ATXN1
CDK1
CDK2
EIF4EBP1
KEAP1
LCOR
MAPKAP1
MTOR
PRMT1
RPS6KA3
RPTOR
Entrez ID
2
64223
HPRD ID
00072
17031
Ensembl ID
ENSG00000175899
ENSG00000167965
Uniprot IDs
P01023
H3BPT1
Q9BVC4
PDB IDs
1BV8
2P9R
6TAV
7O7L
7O7M
7O7N
7O7O
7O7P
7O7Q
7O7R
7O7S
7VON
7VOO
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5H64
5WBU
5WBY
5ZCS
6BCU
6BCX
6SB0
6SB2
6ZWM
6ZWO
7OWG
7PE7
7PE8
7PE9
7PEA
7PEB
7PEC
7TZO
7UXC
7UXH
8ERA
8RCH
8RCK
9F44
9F45
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Multicellular Organismal Process
Extracellular Exosome
Extracellular Space
Peptidase Activity
Ovulation From Ovarian Follicle
Regulation Of Cell Activation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Hydrolase Activity
Ovulation
Regulation Of Multicellular Organismal Process
Response To Stress
Regulation Of Blood Coagulation
Negative Regulation Of Platelet Activation
Regulation Of Hemostasis
Extracellular Region
Regulation Of Amyloid-beta Clearance
Positive Regulation Of Cell Adhesion
Smooth Muscle Adaptation
Regulation Of Programmed Cell Death
Regulation Of Immune Response
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Proteolysis
Negative Regulation Of Coagulation
Regulation Of Cell Adhesion
Regulation Of Biological Quality
Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Apoptotic Process
Positive Regulation Of Cell Activation
Identical Protein Binding
Positive Regulation Of Protein Metabolic Process
Protein Refolding
Positive Regulation Of Cell Migration
Positive Regulation Of Multicellular Organismal Process
Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Lymphocyte Activation
Regulation Of Transport
Melanosome
Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Smooth Muscle Cell Proliferation
Serine-type Endopeptidase Activity
Positive Regulation Of Cell Motility
Extracellular Matrix
Lipoprotein Particle
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Regulation Of Nitric Oxide Metabolic Process
TOR Signaling
Negative Regulation Of Translational Initiation
TORC1 Signaling
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Serine/threonine Protein Kinase Complex
Positive Regulation Of Growth
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Translational Initiation
Cellular Response To Oxygen-containing Compound
Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Metabolic Process
Positive Regulation Of Pentose-phosphate Shunt
Regulation Of Cell Differentiation
Positive Regulation Of Cell Growth
Negative Regulation Of Cellular Response To Insulin Stimulus
Histone Kinase Activity
TORC1 Complex
Regulation Of Pentose-phosphate Shunt
Cellular Response To Methionine
Negative Regulation Of Translation
Regulation Of Translation
Intracellular Signal Transduction
Response To Methionine
Regulation Of NADP Metabolic Process
Positive Regulation Of TORC1 Signaling
TORC2 Complex
Regulation Of Mitotic Cell Cycle
Regulation Of Cellular Response To Insulin Stimulus
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Multicellular Organismal Development
Cellular Response To Amino Acid Stimulus
Cell Cycle G1/S Phase Transition
Cellular Response To Nutrient Levels
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To L-leucine
Positive Regulation Of TOR Signaling
Cellular Response To Chemical Stress
Regulation Of Primary Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of TORC1 Signaling
Regulation Of Growth
Post-transcriptional Regulation Of Gene Expression
TORC2 Signaling
Response To L-leucine
Nucleoplasm
Positive Regulation Of Transcription By RNA Polymerase III
Enzyme-substrate Adaptor Activity
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Tagcloud (Intersection)
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