A2M and SLC6A4

Number of citations of the paper that reports this interaction (PubMedID 7686585)
0

Data Source:
BioGRID (pull down)

		A2M	SLC6A4
Description		alpha-2-macroglobulin	solute carrier family 6 member 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Endosome Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Membrane Presynaptic Membrane Cell Projection Neuron Projection Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Serotonergic Synapse
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Integrin Binding Monoatomic Cation Channel Activity Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Antiporter Activity Syntaxin-1 Binding Cocaine Binding Sodium Ion Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation	Response To Hypoxia Neurotransmitter Transport Serotonin Transport Amino Acid Transport Response To Nutrient Memory Circadian Rhythm Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Sodium Ion Transmembrane Transport Vasoconstriction Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Behavioral Response To Cocaine Enteric Nervous System Development Brain Morphogenesis Serotonin Uptake Membrane Depolarization Male Mating Behavior Platelet Aggregation Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size Neurotransmitter Reuptake Conditioned Place Preference
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly	Serotonin clearance from the synaptic cleft SLC-mediated transport of neurotransmitters
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
Diseases
GWAS		Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196)
Interacting Genes		99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40	7 interacting genes: A2M CALR CANX GPM6B STX1A VAMP2 YBX1
Entrez ID		2	6532
HPRD ID		00072	01640
Ensembl ID		ENSG00000175899	ENSG00000108576
Uniprot IDs		P01023	B2R7Y7 P31645
PDB IDs		1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO	5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C 7LI6 7LI7 7LI8 7LI9 7LIA 7LWD 7MGW 7TXT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process	Intracellular Protein Localization Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Protein Transport Establishment Of Protein Localization Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Protein Folding In Endoplasmic Reticulum SNARE Complex Assembly Protein Localization To Extracellular Region Protein Secretion Secretion By Cell Establishment Of Protein Localization To Extracellular Region Signal Release Endoplasmic Reticulum Quality Control Compartment Secretion Lumenal Side Of Endoplasmic Reticulum Membrane Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis SNAP Receptor Activity SNARE Complex Insulin Secretion SNARE Binding Peptide Hormone Secretion Myosin Head/neck Binding Peptide Secretion Voltage-gated Potassium Channel Complex Negative Regulation Of Complement Activation, Lectin Pathway ERAD Pathway Endocytosis Hormone Secretion Hormone Transport Homomeric SMAD Protein Complex Peptide Transport Organelle Membrane Fusion Regulated Exocytosis Vesicle Fusion Secretory Granule Interleukin-8 Binding Unfolded Protein Binding Response To Biphenyl Regulation Of Ossification Negative Regulation Of Serotonin Uptake Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis MiRNA Transport
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