A2M and LCAT

Number of citations of the paper that reports this interaction (PubMedID 11435418)
0

Data Source:
HPRD (in vivo, in vitro)

		A2M	LCAT
Description		alpha-2-macroglobulin	lecithin-cholesterol acyltransferase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Phospholipase A2 Activity Sterol Ester Esterase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Aflatoxin Metabolic Process Phosphatidylcholine Metabolic Process Response To Copper Ion Response To Glucocorticoid Regulation Of High-density Lipoprotein Particle Assembly
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly	HDL remodeling
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS		Refractive error ( 32231278)	HDL cholesterol ( 19060906 25961943 24507774 24097068 21347282 20864672 20686565 19060910 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40	4 interacting genes: A2M APOA1 APOE EXOSC10
Entrez ID		2	3931
HPRD ID		00072	06098
Ensembl ID		ENSG00000175899	ENSG00000213398
Uniprot IDs		P01023	A0A140VK24 P04180
PDB IDs		1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO	4X96 4XWG 4XX1 5BV7 5TXF 6MVD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process	Positive Regulation Of Phospholipid Efflux Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Lipoprotein Particle Binding Blood Microparticle High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Reverse Cholesterol Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Negative Regulation Of Defense Response Cholesterol Efflux Positive Regulation Of Cholesterol Metabolic Process Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Efflux Signaling Receptor Binding Enzyme Binding Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Positive Regulation Of Lipid Transport Phospholipid Transport Amyloid-beta Binding Extracellular Vesicle Regulation Of Rho Protein Signal Transduction Cholesterol Homeostasis
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