A2M and PRDX2

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		A2M	PRDX2
Gene Name		alpha-2-macroglobulin	peroxiredoxin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Response To Reactive Oxygen Species Response To Oxidative Stress Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oxidation-reduction Process
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation	Detoxification of Reactive Oxygen Species
Drugs		Becaplermin Bacitracin Ocriplasmin	3-Sulfinoalanine N-Carbamoyl-Alanine
Diseases
GWAS
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	23 interactors: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 UTY YWHAZ
Entrez ID		2	7001
HPRD ID		00072	02763
Ensembl ID		ENSG00000175899	ENSG00000167815
Uniprot IDs		P01023	A6NIW5 B4DF70 P32119
PDB IDs		1BV8 2P9R 4ACQ	1QMV
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Establishment Of Localization In Cell Secretion By Cell Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Cell Death Secretion Intracellular Signal Transduction Cellular Localization Cellular Component Assembly Vesicle-mediated Transport Regulation Of Cellular Component Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Response To Oxidative Stress Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase Activity Synapse Assembly Protein Metabolic Process Positive Regulation Of Signal Transduction Membrane Organization Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Regulation Of Catalytic Activity Homeostatic Process Anatomical Structure Morphogenesis Positive Regulation Of Apoptotic Process Regulation Of Receptor Activity Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Cell Death Anion Transport Regulation Of Proteolysis Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Mitochondrial Transport Postsynaptic Membrane Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically predictedinteractions scrutinized searching slowing snca string sum tof
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically predictedinteractions scrutinized searching slowing snca string sum tof
Tagcloud (Intersection) ?