A2M and KLK2

Number of citations of the paper that reports this interaction (PubMedID 9428387)
0

Data Source:
HPRD (in vitro)

		A2M	KLK2
Description		alpha-2-macroglobulin	kallikrein related peptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Refractive error ( 32231278)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		2	3817
HPRD ID		00072	01006
Ensembl ID		ENSG00000175899	ENSG00000167751
Uniprot IDs		P01023	A0A024R4J4 B4DU77 P20151
PDB IDs		1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO	4NFE 4NFF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization
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