A2M and LONP1

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		A2M	LONP1
Gene Name		alpha-2-macroglobulin	lon peptidase 1, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Nucleoid
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding ADP Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding Mitochondrial Light Strand Promoter Anti-sense Binding Mitochondrial Heavy Strand Promoter Anti-sense Binding Mitochondrial Light Strand Promoter Sense Binding Mitochondrial Heavy Strand Promoter Sense Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Mitochondrial Genome Maintenance Response To Hypoxia Misfolded Or Incompletely Synthesized Protein Catabolic Process Mitochondrion Organization Aging Response To Hormone Response To Aluminum Ion Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Chaperone-mediated Protein Complex Assembly Protein Homooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Oxidation-dependent Protein Catabolic Process Regulation Of Mitochondrial DNA Replication
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs		Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	10 interactors: A2M APOE CDC37 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF32
Entrez ID		2	9361
HPRD ID		00072	05689
Ensembl ID		ENSG00000175899	ENSG00000196365
Uniprot IDs		P01023	B3KPH8 F5GZ27 P36776 Q8N8K8
PDB IDs		1BV8 2P9R 4ACQ	2X36
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Maintenance Of Location In Cell Defense Response To Virus Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Tau-protein Kinase Activity Regulation Of Presynaptic Membrane Organization Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Very-low-density Lipoprotein Particle Remodeling Innate Immune Response Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Response To External Stimulus Positive Regulation Of Phospholipid Transport Omega-hydroxylase P450 Pathway Chylomicron Remnant Clearance Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cellular Response To Interferon-alpha Regulation Of Innate Immune Response Negative Regulation Of Beta-amyloid Formation CGMP-mediated Signaling Exit From Mitosis Low-density Lipoprotein Particle Remodeling Cholesterol Catabolic Process Response To Virus Negative Regulation Of Cholesterol Transport Establishment Of Localization In Cell
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen
Tagcloud (Intersection) ?