A2M and IL4

Number of citations of the paper that reports this interaction (PubMedID 10714547)
0

Data Source:
BioGRID (pull down)

		A2M	IL4
Description		alpha-2-macroglobulin	interleukin 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Cytokine Activity Cytokine Receptor Binding Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Interleukin-4-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Macrophage Activation Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Isotype Switching Leukocyte Activation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of ATP Biosynthetic Process
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Pascolizumab Dupilumab Romilkimab
Diseases			Asthma
GWAS		Refractive error ( 32231278)	Asthma ( 29273806 31619474 31959851) Asthma (childhood onset) ( 29273806 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)
Interacting Genes		99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40	7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD
Entrez ID		2	3565
HPRD ID		00072	00989
Ensembl ID		ENSG00000175899	ENSG00000113520
Uniprot IDs		P01023	D4HNR6 P05112 Q5FC01 U3LVN1
PDB IDs		1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL 8A4F 8CGF 8CH7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process	Regulation Of Immune System Process Interleukin-4 Receptor Activity Negative Regulation Of Immune System Process Cytokine Receptor Activity Lymphocyte Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Immunoglobulin Production Mononuclear Cell Differentiation Leukocyte Differentiation Negative Regulation Of Hemopoiesis Positive Regulation Of Myoblast Fusion Regulation Of Hemopoiesis Lymphocyte Activation Leukocyte Mediated Immunity Regulation Of Myoblast Fusion Immune System Process T Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Lymphocyte Activation Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Activation Receptor Complex Regulation Of Mast Cell Degranulation Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Cell Activation Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cytokine Binding Positive Regulation Of T Cell Activation B Cell Mediated Immunity Negative Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cell Development Negative Regulation Of Lymphocyte Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Alpha-beta T Cell Differentiation Cellular Developmental Process
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