A2M and NCDN

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		A2M	NCDN
Description		alpha-2-macroglobulin	neurochondrin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Nucleus Cytoplasm Endosome Cytosol Endosome Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation	Neuron Projection Development Bone Resorption Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40	13 interacting genes: A2M ACD EFHC2 KRT75 LYST PAX6 POT1 PREX1 SEMA4C TINF2 TLE5 ZBED1 ZNF398
Entrez ID		2	23154
HPRD ID		00072	10530
Ensembl ID		ENSG00000175899	ENSG00000020129
Uniprot IDs		P01023	Q9UBB6
PDB IDs		1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Cell Motility Telomere Maintenance Via Telomerase Telomere Organization Negative Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Cell Migration Leukocyte Migration Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein Autosumoylation Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Mast Cell Secretory Granule Organization Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Interleukin-8 Binding Chemotaxis Habenula Development Pallium Development DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome Organization Locomotion
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