FIS1 and TBC1D15

Number of citations of the paper that reports this interaction (PMID 23077178)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FIS1	TBC1D15
Gene Name		fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	TBC1 domain family, member 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Membrane Integral Component Of Mitochondrial Outer Membrane Protein Complex	Cytoplasm Mitochondrion Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding	Rab GTPase Activator Activity Protein Binding
	Biological Process	Mitochondrial Fission Mitochondrion Degradation Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Rab GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M BCAP31 CCDC155 DNM1L MARCH5 NOS3 PEX5 TBC1D15 UBC VKORC1	7 interactors: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C
Entrez ID		51024	64786
HPRD ID		12352	15470
Ensembl ID		ENSG00000214253	ENSG00000121749
Uniprot IDs		Q9Y3D6	Q8TC07
PDB IDs		1NZN 1PC2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Fission Cellular Localization Regulation Of Mitochondrial Fission Protein Localization To Organelle Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Protein Localization To Mitochondrion Execution Phase Of Apoptosis Chromosome Localization To Nuclear Envelope Involved In Synapsis Mitochondrial Membrane Fission Dynamin Polymerization Involved In Mitochondrial Fission Oogenesis Mitochondrion Organization Blood Coagulation Regulation Of Signaling Hemostasis Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Negative Regulation Of Protein Homotetramerization Smooth Muscle Hyperplasia Negative Regulation Of Complement Activation, Lectin Pathway Protein Tetramerization Female Gamete Generation Spermatogenesis Male Gamete Generation Regulation Of Peroxisome Organization Protein Import Into Peroxisome Matrix, Translocation Regulation Of Body Fluid Levels Second-messenger-mediated Signaling Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Cellular Protein Localization Smooth Muscle Adaptation Protein Import Into Peroxisome Matrix, Docking Wound Healing Positive Regulation Of Cell Death Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Intrinsic Apoptotic Signaling Pathway Gamete Generation Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Protein Polyubiquitination Regulation Of Proteolysis	Cytoplasmic Transport Rab Protein Signal Transduction Plasma Membrane To Endosome Transport Intracellular Protein Transport Cellular Protein Localization Protein Transport Regulation Of Endocytosis Establishment Of Protein Localization Intracellular Transport Endosomal Transport Ras Protein Signal Transduction Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Response To Stimulus Cellular Localization Vesicle-mediated Transport G2/M Transition Of Mitotic Cell Cycle Small GTPase Mediated Signal Transduction Response To Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Autophagy Negative Regulation Of Receptor Recycling Regulation Of Cellular Component Organization Golgi Ribbon Formation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Mitochondrial Fission Mitochondrial Fragmentation Involved In Apoptotic Process Wnt Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Peroxisome Fission Centriole Replication Regulation Of Mitochondrial Fission Calcium-mediated Signaling Using Intracellular Calcium Source Establishment Of Protein Localization To Organelle Mitochondrial Calcium Ion Homeostasis Mitochondrial Fusion Transport Early Endosome To Late Endosome Transport Centriole Assembly Protein Targeting Endomembrane System Organization Protein Targeting To Golgi
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1
Tagcloud (Intersection) ?