FIS1 and TBC1D15

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, affinity chromatography technology, pull down)

		FIS1	TBC1D15
Description		fission, mitochondrial 1	TBC1 domain family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex	Extracellular Region Cytoplasm
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Molecular Adaptor Activity	GTPase Activator Activity Protein Binding
	Biological Process	Mitochondrial Fission Protein Targeting To Mitochondrion Apoptotic Process Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Cellular Response To Glucose Stimulus Cellular Response To Lipid Positive Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Negative Regulation Of ATP Metabolic Process Response To Flavonoid Response To Hypobaric Hypoxia Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Class I peroxisomal membrane protein import	TBC/RABGAPs
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 30891314)	Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)
Interacting Genes		31 interacting genes: A2M ABHD6 APH1A AQP6 BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1	9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC
Entrez ID		51024	64786
HPRD ID		12352	15470
Ensembl ID		ENSG00000214253	ENSG00000121749
Uniprot IDs		Q9Y3D6	A8K8E1 Q8TC07
PDB IDs		1NZN 1PC2 7YA9 7YKA 8U1Z 8XWX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Monoatomic Ion Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Monoatomic Cation Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Endoplasmic Reticulum Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Golgi Membrane Transmembrane Transport Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Mitochondrial Outer Membrane Dopamine Transport Neurotransmitter Reuptake Metal Ion Transport Positive Regulation Of Mitochondrial Fission Neutrophil Mediated Immunity Xenobiotic Transmembrane Transporter Activity Water Transport One-carbon Compound Transport Cellular Detoxification Positive Regulation Of Protein Transport	Plasma Membrane To Endosome Transport GDP Binding Endocytic Vesicle G Protein Activity Melanosome Early Endosome Membrane Establishment Of Protein Localization Endomembrane System Endosomal Transport Endosome Early Endosome GTPase Activity GTP Binding Endosome Organization Autophagosome Intracellular Protein Localization Protein Localization To Phagocytic Vesicle Negative Regulation Of Canonical NF-kappaB Signal Transduction Endocytosis Protein Transport Protein Localization To Early Endosome Response To Flavonoid Cytoplasmic Side Of Early Endosome Membrane Vesicle-mediated Transport Extracellular Exosome Synaptic Vesicle Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Negative Regulation Of Receptor Recycling Type 2 Mitophagy Response To Fluoride Response To Hypobaric Hypoxia Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Protein Localization To Organelle Import Into Cell Amyloid-beta Clearance By Transcytosis Innate Immune Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Xenophagy Molecular Adaptor Activity Negative Regulation Of Fatty Acid Transport Cellular Response To Peptide Negative Regulation Of Protein Polyubiquitination Regulation Of Endosome Size Cytosol Cellular Localization Organelle Organization Mitochondrial Outer Membrane
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