A2M and ANXA6

Number of citations of the paper that reports this interaction (PMID 15226301)
1

Data Source:
HPRD (in vitro)

		A2M	ANXA6
Gene Name		alpha-2-macroglobulin	annexin A6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Lysosomal Membrane Focal Adhesion Membrane Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Ion Channel Activity Cholesterol Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Calcium Ion Transport Regulation Of Muscle Contraction Ion Transmembrane Transport Protein Homooligomerization
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs		Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	9 interactors: A2M CDC73 CR2 MLH1 RASA1 S100A1 S100B SNCA TPD52
Entrez ID		2	309
HPRD ID		00072	00231
Ensembl ID		ENSG00000175899	ENSG00000197043
Uniprot IDs		P01023	A6NN80 P08133
PDB IDs		1BV8 2P9R 4ACQ	1M9I
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Developmental Process Cell Activation Leukocyte Activation B Cell Activation Cell Differentiation Protein Destabilization Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Meiotic Metaphase I Plate Congression Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Meiotic Spindle Midzone Assembly MRNA 3'-end Processing Lymphocyte Activation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transport Immune System Process B Cell Differentiation RNA 3'-end Processing Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Mitotic Recombination Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Synaptic Transmission Immune Response Regulation Of Immune System Process Signaling Cell Communication Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Regulation Of Protein Stability Response To Stimulus Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Skeletal Muscle Cell Differentiation System Development Regulation Of Cell Shape Regulation Of Synaptic Plasticity Protein Activation Cascade Regulation Of Signal Transduction
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	1q21 5q31 6p21 alleles applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	1q21 5q31 6p21 alleles applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Intersection) ?