A2M and MGEA5

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		A2M	MGEA5
Gene Name		alpha-2-macroglobulin	meningioma expressed antigen 5 (hyaluronidase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytosol Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Histone Acetyltransferase Activity Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	N-acetylglucosamine Metabolic Process Glycoprotein Catabolic Process Protein Deglycosylation Protein Targeting To Membrane Aging Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Adaptation Histone Acetylation Positive Regulation Of Cell Killing Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Proteolysis DATP Metabolic Process Positive Regulation Of Glucose Import Response To Steroid Hormone Positive Regulation Of DNA Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Glycosylation Positive Regulation Of Growth Hormone Secretion Necrotic Cell Death
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs		Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	10 interactors: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32
Entrez ID		2	10724
HPRD ID		00072	04949
Ensembl ID		ENSG00000175899	ENSG00000198408
Uniprot IDs		P01023	E9PGF9 O60502
PDB IDs		1BV8 2P9R 4ACQ	2YDQ
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Regulation Of Protein Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Axon Guidance Regulation Of Cellular Protein Metabolic Process Axonogenesis Circadian Rhythm Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Metabolic Process Regulation Of Complement Activation Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Binding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Regulation Of Humoral Immune Response Regulation Of Signal Transduction Rhythmic Process Cell Projection Morphogenesis Negative Regulation Of Protein Binding Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Response To External Stimulus Cellular Response To Heat Neuron Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Acute Inflammatory Response Regulation Of Generation Of Precursor Metabolites And Energy Cell Morphogenesis Regulation Of Protein Phosphorylation Cell Differentiation Neuron Differentiation Cell Projection Organization Negative Regulation Of Binding Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Negative Regulation Of Complement Activation, Lectin Pathway Locomotion Establishment Of Cell Polarity Response To Heat
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Intersection) ?