FIS1 and DNM1L

Number of citations of the paper that reports this interaction (PMID 12861026)
151

Data Source:
HPRD (in vitro, in vivo)

		FIS1	DNM1L
Gene Name		fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	dynamin 1-like
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Membrane Integral Component Of Mitochondrial Outer Membrane Protein Complex	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Golgi Apparatus Cytosol Microtubule Coated Pit Membrane Cell Junction Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding	GTPase Activity Protein Binding GTP Binding Lipid Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitochondrial Fission Mitochondrion Degradation Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Dynamin Polymerization Involved In Mitochondrial Fission Endocytosis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Mitochondrion Organization Peroxisome Fission Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Protein Secretion Protein Homotetramerization Membrane Fusion Necroptotic Process Mitochondrion Morphogenesis Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Peroxisome Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M BCAP31 CCDC155 DNM1L MARCH5 NOS3 PEX5 TBC1D15 UBC VKORC1	15 interactors: FIS1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF2 MUL1 PARK2 RRM2 SCG3 SH3GL1 SIRT3 VIM ZBTB24
Entrez ID		51024	10059
HPRD ID		12352	04833
Ensembl ID		ENSG00000214253	ENSG00000087470
Uniprot IDs		Q9Y3D6	B4DGC9 B4DYR6 G8JLD5 J3KPI2 O00429 Q59GN9
PDB IDs		1NZN 1PC2	4BEJ 4H1U 4H1V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Fission Cellular Localization Regulation Of Mitochondrial Fission Protein Localization To Organelle Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Protein Localization To Mitochondrion Execution Phase Of Apoptosis Chromosome Localization To Nuclear Envelope Involved In Synapsis Mitochondrial Membrane Fission Dynamin Polymerization Involved In Mitochondrial Fission Oogenesis Mitochondrion Organization Blood Coagulation Regulation Of Signaling Hemostasis Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Negative Regulation Of Protein Homotetramerization Smooth Muscle Hyperplasia Negative Regulation Of Complement Activation, Lectin Pathway Protein Tetramerization Female Gamete Generation Spermatogenesis Male Gamete Generation Regulation Of Peroxisome Organization Protein Import Into Peroxisome Matrix, Translocation Regulation Of Body Fluid Levels Second-messenger-mediated Signaling Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Cellular Protein Localization Smooth Muscle Adaptation Protein Import Into Peroxisome Matrix, Docking Wound Healing Positive Regulation Of Cell Death Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Intrinsic Apoptotic Signaling Pathway Gamete Generation Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Protein Polyubiquitination Regulation Of Proteolysis	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Mitochondrial Fusion Regulation Of Intracellular Transport Regulation Of Mitochondrial Fusion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Apoptotic Process Protein Localization To Mitochondrion Mitochondrial Fragmentation Involved In Apoptotic Process Programmed Cell Death Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Transport Peroxisome Fission Positive Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Signal Transduction Mitochondrial Fusion Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Mitochondrion Morphogenesis Regulation Of JNK Cascade Mitochondrion Degradation Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Mitochondrion Organization Protein Localization To Organelle Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Organelle Disassembly Activation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Peroxisome Organization
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Intersection) ?