TMED5 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TMED5	PRMT6
Description		transmembrane p24 trafficking protein 5	protein arginine methyltransferase 6
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		WNT ligand biogenesis and trafficking	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 29403010)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		3 interacting genes: CXCL9 PRMT6 TMEM132D	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		50999	55170
HPRD ID		13028	10505
Ensembl ID		ENSG00000117500	ENSG00000198890
Uniprot IDs		M0R072 Q9Y3A6	Q96LA8
PDB IDs			4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
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