TMED5 and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		TMED5	TMEM132D
Description		transmembrane p24 trafficking protein 5	transmembrane protein 132D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation
Pathways		WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 29403010)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		3 interacting genes: CXCL9 PRMT6 TMEM132D	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		50999	121256
HPRD ID		13028	13906
Ensembl ID		ENSG00000117500	ENSG00000151952
Uniprot IDs		M0R072 Q9Y3A6	Q14C87
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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