PCBP1 and EWSR1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCBP1	EWSR1
Gene Name		poly(rC) binding protein 1	EWS RNA-binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		36 interactors: ANP32A APP CAV3 CELF2 CELF3 ERG EWSR1 GNB2 HMGA1 HNRNPD HNRNPK HNRNPLL LMNA MATR3 NOVA1 PABPC1 PCBP2 PCBP4 PDLIM7 PPIG PPIL3 PRPF3 PTBP1 PUF60 QKI RALY RBM11 RBM42 SNRPA SRSF3 TCERG1 TSC22D4 UGP2 ZCCHC10 ZNF384 ZNF830	159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		5093	2130
HPRD ID		03128	00592
Ensembl ID		ENSG00000169564	ENSG00000182944
Uniprot IDs		Q15365 Q53SS8	Q01844
PDB IDs		1WVN 1ZTG 3VKE	2CPE
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Macromolecule Biosynthetic Process Negative Regulation Of Potassium Ion Transmembrane Transport MRNA 3'-end Processing RNA Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Ventricular Cardiac Muscle Cell Action Potential RNA 3'-end Processing Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Translation Cellular Process Cardiac Muscle Cell Action Potential Involved In Contraction Biosynthetic Process MRNA Polyadenylation Positive Regulation Of RNA Splicing Cardiac Muscle Cell Action Potential RNA Polyadenylation	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?		atypical au element encoding eta half knockdown markedly owing pigmentosum polh poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Difference) ?		atypical au element encoding eta half knockdown markedly owing pigmentosum polh poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Intersection) ?