PCBP1 and PRPF3

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		PCBP1	PRPF3
Description		poly(rC) binding protein 1	pre-mRNA processing factor 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Nuclear Speck Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Cadherin Binding Sequence-specific Single Stranded DNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Viral RNA Genome Replication Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Male-pattern baldness ( 28196072)	Alanine aminotransferase levels ( 33339817) Ambidextrousness ( 32989287) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ANP32A APP ARIH1 BCL2L13 CAV3 CELF2 CELF3 DARS1-AS1 ERG EWSR1 FTH1 GNB2 HMGA1 HMGB2 HNRNPD HNRNPK HNRNPLL HSPA13 HYPK IGF2BP3 KLF1 LMNA MATR3 NOVA1 OGT PABPC1 PCBP2 PCBP4 PDLIM7 PPIG PPIL3 PRPF3 PTBP1 PUF60 QKI RALY RBFOX2 RBM10 RBM11 RBM14 RBM3 RBM42 RBPMS2 SIVA1 SNCG SNRPA SRPK2 SRSF3 TCERG1 TLE5 TNFAIP3 TSC22D4 UGP2 ZCCHC10 ZNF384 ZNF830	50 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEBPA CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT
Entrez ID		5093	9129
HPRD ID		03128	07389
Ensembl ID		ENSG00000169564	ENSG00000117360
Uniprot IDs		Q15365 Q53SS8	O43395
PDB IDs		1WVN 1ZTG 3VKE	1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7N2N 7N2R 7N2S 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Metabolic Process RNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck MRNA Stabilization Negative Regulation Of Gene Expression MRNA 3'-UTR Binding CRD-mediated MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing Spliceosomal Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Assembly Nucleus MRNA Processing Hematopoietic Stem Cell Proliferation Nucleoplasm Protein Binding U4 SnRNA Binding Positive Regulation Of Neuron Projection Arborization U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process Centrosome Cycle Protein Domain Specific Binding RNA Metabolic Process Prp19 Complex RNA Processing Protein Localization To Microtubule Cytoplasm Protein-containing Complex Assembly Regulation Of Neuron Projection Arborization
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