LTBP4 and CTDSP1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		LTBP4	CTDSP1
Description		latent transforming growth factor beta binding protein 4	CTD small phosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Extracellular Matrix	Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Transforming Growth Factor Beta Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Growth Factor Binding Transforming Growth Factor Beta Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hormone Secretion Elastic Fiber Assembly	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of Neurogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Drugs			Aspartate beryllium trifluoride Citric acid
Diseases		Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)	Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin concentration ( 27863252 32888494)
Interacting Genes		16 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 CTDSP1 FBLN1 FRAT1 GFI1B HOXA1 ITSN2 MBD1 NUFIP2 RAC1 SHANK3 TGFB1	43 interacting genes: ACTN3 BAG3 CDCA3 CDKN2C CRYBA2 CSF1R CSTF2T FAAP20 FAM110A FANCL FGFR2 GPSM1 GTF2F1 HUNK ITPKB LCK LDB1 LRRC73 LTBP4 MAPKBP1 MBP MORN3 NOXA1 OSTF1 PDZD4 PLEKHM1 POLR2A PTPN11 RAB3IL1 RPRD2 SAXO4 SCNM1 SDCBP SNAI1 STRA8 TEKT4 TRAPPC6A TYRO3 USP29 WWOX YPEL5 ZBTB16 ZSWIM8
Entrez ID		8425	58190
HPRD ID		05274	05615
Ensembl ID		ENSG00000090006	ENSG00000144579
Uniprot IDs		A0A0C4DH07 B3KXY6 Q8N2S1	Q9GZU7
PDB IDs			1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL 4YGY 4YH1 6DU3
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Interleukin-23 Production Postsynaptic Specialization Assembly Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Organization Regulation Of Leukocyte Migration Helper T Cell Diapedesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Dendrite Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization To Membrane Regulation Of Cell-substrate Adhesion Establishment Or Maintenance Of Cell Polarity Blue Light Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transformation Of Host Cell By Virus Cochlea Morphogenesis Semicircular Canal Formation Abducens Nerve Formation Inner Ear Development Optokinetic Behavior Positive Regulation Of Ovarian Follicle Development Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Interleukin-23 Production Negative Regulation Of Endocytosis Regulation Of Cell Development Regulation Of Fibroblast Migration Regulation Of ERK5 Cascade
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