LTBP4 and FRAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LTBP4	FRAT1
Description		latent transforming growth factor beta binding protein 4	FRAT regulator of Wnt signaling pathway 1
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Extracellular Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function	Transforming Growth Factor Beta Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Growth Factor Binding Transforming Growth Factor Beta Binding	Protein Binding Molecular Function Inhibitor Activity
	Biological Process	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hormone Secretion Elastic Fiber Assembly	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases		Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)	Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 CTDSP1 FBLN1 FRAT1 GFI1B HOXA1 ITSN2 MBD1 NUFIP2 RAC1 SHANK3 TGFB1	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		8425	10023
HPRD ID		05274	03935
Ensembl ID		ENSG00000090006	ENSG00000165879
Uniprot IDs		A0A0C4DH07 B3KXY6 Q8N2S1	Q92837
PDB IDs			1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Interleukin-23 Production Postsynaptic Specialization Assembly Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Organization Regulation Of Leukocyte Migration Helper T Cell Diapedesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Dendrite Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization To Membrane Regulation Of Cell-substrate Adhesion Establishment Or Maintenance Of Cell Polarity Blue Light Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transformation Of Host Cell By Virus Cochlea Morphogenesis Semicircular Canal Formation Abducens Nerve Formation Inner Ear Development Optokinetic Behavior Positive Regulation Of Ovarian Follicle Development Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Interleukin-23 Production Negative Regulation Of Endocytosis Regulation Of Cell Development Regulation Of Fibroblast Migration Regulation Of ERK5 Cascade	Wnt Signalosome
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