CHIC2 and CATSPER1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CHIC2	CATSPER1
Gene Name		cysteine-rich hydrophobic domain 2	cation channel, sperm associated 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Golgi-associated Vesicle Plasma Membrane	Plasma Membrane Motile Cilium CatSper Complex
	Molecular Function	Molecular_function Protein Binding	Calcium Activated Cation Channel Activity Voltage-gated Calcium Channel Activity Protein Binding
	Biological Process	Golgi To Plasma Membrane Transport Biological_process	Multicellular Organismal Development Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Cell Differentiation Sperm Motility Multicellular Organism Reproduction Regulation Of Ion Transmembrane Transport Sperm-egg Recognition Regulation Of Calcium Ion Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways			Sperm Motility And Taxes Fertilization
Drugs
Diseases
GWAS		Blood pressure ( 21909110)
Protein-Protein Interactions		26 interactors: CATSPER1 CDR2 CEP44 GMCL1 HOXA1 ITSN2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 MDFI MEOX2 NOTCH2NL OTX1 PLEKHF2 PNMA1 SPERT TCF4 TOP3B TUBGCP4 U2AF2	33 interactors: ADAMTSL4 AGR2 APOA2 BEGAIN CHIC2 CHRD EFEMP2 EMD KHDRBS2 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PLSCR1 PLSCR3 RFX6 RGS20 RIMBP3 SCRG1 SPRY2 TRAF2 TRIP6
Entrez ID		26511	117144
HPRD ID		10373	09396
Ensembl ID		ENSG00000109220	ENSG00000175294
Uniprot IDs		Q9UKJ5	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Organ Morphogenesis Pattern Specification Process Embryonic Organ Development Anterior/posterior Pattern Specification Embryo Development Embryonic Morphogenesis Optokinetic Behavior Abducens Nerve Formation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Facial Nucleus Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Diencephalon Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Inner Ear Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Rhombomere 4 Development Semicircular Canal Formation Developmental Process Rhombomere 3 Development Rhombomere 5 Development Maintenance Of DNA Repeat Elements Positive Regulation Of Metabolic Process Embryonic Skeletal System Morphogenesis Ear Morphogenesis Organ Morphogenesis Metencephalon Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Somite Specification Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Blood Vessel Development Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Vasculature Development Diencephalon Morphogenesis Embryonic Genitalia Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Embryonic Skeletal System Development Myoblast Fate Commitment Hindbrain Development Single Organism Reproductive Process Embryonic Neurocranium Morphogenesis Secretory Granule Localization	Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Phospholipid Scrambling Regulation Of Protein Localization Phospholipid Transport Regulation Of Cellular Localization Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Signaling Regulation Of Protein Localization To Nucleus Glandular Epithelial Cell Differentiation Regulation Of Nucleocytoplasmic Transport BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Pancreatic Epsilon Cell Differentiation Negative Regulation Of Cholesterol Transporter Activity Pancreatic D Cell Differentiation I-kappaB Kinase/NF-kappaB Signaling Regulation Of Intracellular Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Membrane Lipid Distribution Negative Regulation Of Protein Import Into Nucleus Mucus Secretion Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Acute Inflammatory Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Epithelium Development Cholesterol Homeostasis Lipid Transport Sterol Homeostasis Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Lipid Localization Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Lung Goblet Cell Differentiation Regulation Of Cholesterol Import Negative Regulation Of Intracellular Protein Transport Tissue Development Regulation Of Transcription Factor Import Into Nucleus Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Lobar Bronchus Development Release Of Cytoplasmic Sequestered NF-kappaB Diacylglycerol Catabolic Process Lipid Homeostasis
Tagcloud ?			5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?			5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?