OTX1 and COMP

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OTX1	COMP
Gene Name		orthodenticle homeobox 1	cartilage oligomeric matrix protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	Protease Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Diencephalon Morphogenesis	Skeletal System Development Growth Plate Cartilage Development Apoptotic Process Cell Adhesion Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of Apoptotic Process Limb Development
Pathways			ECM proteoglycans Integrin cell surface interactions
Drugs			Calcium
Diseases
GWAS
Protein-Protein Interactions		39 interactors: CHIC2 CHRD COMP GEMIN8P4 GRN KCNK16 KRT81 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4	4 interactors: COL2A1 COL9A1 FN1 OTX1
Entrez ID		5013	1311
HPRD ID		08964	02632
Ensembl ID		ENSG00000115507	ENSG00000105664
Uniprot IDs		P32242	B4DKJ3 P49747
PDB IDs			3FBY
Enriched GO Terms of Interacting Partners?		Keratinization Keratinocyte Differentiation Epithelium Development Epidermis Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Tissue Development Epidermal Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Skin Development Organ Development Developmental Process Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Development Branch Elongation Of An Epithelium Negative Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Negative Regulation Of Signaling Negative Regulation Of GTPase Activity Axis Elongation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Multicellular Organismal Development Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway System Development Spindle Localization BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Epithelial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Ras Protein Signal Transduction Organ Morphogenesis Negative Regulation Of Small GTPase Mediated Signal Transduction Lung Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Developmental Growth Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Organ Growth Regulation Of GTPase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Establishment Of Cell Polarity	Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Embryonic Morphogenesis Multicellular Organismal Metabolic Process Nervous System Development Inner Ear Morphogenesis Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Bone Morphogenesis Ear Morphogenesis Organ Morphogenesis Tissue Homeostasis Cell Morphogenesis Inner Ear Development Cartilage Development Embryo Development Bone Development Locomotion Ear Development Multicellular Organismal Homeostasis Calcium-independent Cell-matrix Adhesion Connective Tissue Development Skeletal System Morphogenesis Movement Of Cell Or Subcellular Component System Development Diencephalon Morphogenesis Embryonic Organ Morphogenesis Generation Of Neurons Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Multicellular Organismal Development Cell Development Anatomical Structure Development Integrin Activation Embryonic Organ Development Otic Vesicle Development Axonogenesis Developmental Process Growth Plate Cartilage Development Skeletal System Development Embryonic Skeletal Joint Morphogenesis Axon Development
Tagcloud ?		17q21 2p15 allowing amplification antecedent bcl11a cdkn2a cgh commd1 diffuse disrupting dlbcl dndlbcl driver encompassing exclusively fl follicular lymphoma never nfkappabeta novo outline paired possessed rel tdlbcl transformation usp34	20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp
Tagcloud (Difference) ?		17q21 2p15 allowing amplification antecedent bcl11a cdkn2a cgh commd1 diffuse disrupting dlbcl dndlbcl driver encompassing exclusively fl follicular lymphoma never nfkappabeta novo outline paired possessed rel tdlbcl transformation usp34	20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp
Tagcloud (Intersection) ?