OTX1 and KRTAP10-4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		OTX1	KRTAP10-4
Description		orthodenticle homeobox 1	keratin associated protein 10-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways			Keratinization
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Leukocyte telomere length ( 32109421)
Interacting Genes		148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34	11 interacting genes: CATSPER1 E4F1 HOXA1 IGSF8 JOSD1 OTX1 RSPO2 WT1 ZNF32 ZNF625 ZSCAN26
Entrez ID		5013	386672
HPRD ID		08964	11190
Ensembl ID		ENSG00000115507	ENSG00000215454
Uniprot IDs		P32242	P60372
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Tube Morphogenesis Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Regulation Of Animal Organ Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Lung Growth Regulation Of RNA Metabolic Process Metencephalon Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Trachea Cartilage Morphogenesis Embryonic Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Branching Morphogenesis Of An Epithelial Tube Double-stranded Methylated DNA Binding S-shaped Body Morphogenesis Zinc Ion Binding Embryonic Neurocranium Morphogenesis Anterior/posterior Pattern Specification Diaphragm Development Regulation Of Female Gonad Development Morphogenesis Of A Branching Structure Positive Regulation Of Male Gonad Development Morphogenesis Of A Branching Epithelium Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Membrane Biogenesis CatSper Complex Outer Ear Morphogenesis
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