OTX1 and LGALS13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX1	LGALS13
Description		orthodenticle homeobox 1	galectin 13
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Phosphatidylcholine Lysophospholipase Activity Protein Binding Carbohydrate Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis	Phospholipid Metabolic Process Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Lead levels ( 26025379)
Interacting Genes		148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34	10 interacting genes: ACTB ACTG1 ANXA2 CREB5 HOXA1 NUFIP2 OTX1 PACSIN3 PHLDA1 POU4F2
Entrez ID		5013	29124
HPRD ID		08964	16375
Ensembl ID		ENSG00000115507	ENSG00000105198
Uniprot IDs		P32242	Q9UHV8
PDB IDs			5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus	Positive Regulation Of Macromolecule Metabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Endocytosis DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Axonogenesis Regulation Of Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Regulation Of Transcription By RNA Polymerase II Regulation Of Vesicle-mediated Transport DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Platelet Aggregation Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Formation Diencephalon Morphogenesis Homotypic Cell-cell Adhesion Negative Regulation Of Endocytosis Cytoskeletal Protein Binding Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Protein Localization To Cell Junction Regulation Of RNA Biosynthetic Process Regulation Of Norepinephrine Uptake Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
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