OTX1 and LCE1B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OTX1	LCE1B
Gene Name		orthodenticle homeobox 1	late cornified envelope 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Diencephalon Morphogenesis	Keratinization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: CHIC2 CHRD COMP GEMIN8P4 GRN KCNK16 KRT81 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4	22 interactors: ADAMTSL4 BEND5 HOXA1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MEOX2 NOTCH2NL OTX1 RGS20 SPRY1 SPRY2
Entrez ID		5013	353132
HPRD ID		08964	17259
Ensembl ID		ENSG00000115507	ENSG00000196734
Uniprot IDs		P32242	Q5T7P3
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Keratinocyte Differentiation Epithelium Development Epidermis Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Tissue Development Epidermal Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Skin Development Organ Development Developmental Process Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Development Branch Elongation Of An Epithelium Negative Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Negative Regulation Of Signaling Negative Regulation Of GTPase Activity Axis Elongation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Multicellular Organismal Development Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway System Development Spindle Localization BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Epithelial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Ras Protein Signal Transduction Organ Morphogenesis Negative Regulation Of Small GTPase Mediated Signal Transduction Lung Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Developmental Growth Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Organ Growth Regulation Of GTPase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Establishment Of Cell Polarity	Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Neurotrophin TRK Receptor Signaling Pathway Embryonic Organ Morphogenesis Bud Elongation Involved In Lung Branching Inner Ear Morphogenesis Ear Morphogenesis Negative Regulation Of Ras GTPase Activity Organ Morphogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Pattern Specification Process Embryonic Organ Development Branch Elongation Of An Epithelium Embryo Development Inner Ear Development Negative Regulation Of GTPase Activity Axis Elongation Embryonic Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Ear Development Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of MAP Kinase Activity Spindle Localization Negative Regulation Of ERK1 And ERK2 Cascade Developmental Process Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Lung Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Optokinetic Behavior Abducens Nerve Formation Regulation Of ERBB Signaling Pathway Negative Regulation Of MAP Kinase Activity Organ Development Tube Morphogenesis Negative Regulation Of Signal Transduction Epithelium Development Multicellular Organismal Development Facial Nucleus Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Establishment Of Cell Polarity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Metabolic Process
Tagcloud ?		17q21 2p15 allowing amplification antecedent bcl11a cdkn2a cgh commd1 diffuse disrupting dlbcl dndlbcl driver encompassing exclusively fl follicular lymphoma never nfkappabeta novo outline paired possessed rel tdlbcl transformation usp34
Tagcloud (Difference) ?		17q21 2p15 allowing amplification antecedent bcl11a cdkn2a cgh commd1 diffuse disrupting dlbcl dndlbcl driver encompassing exclusively fl follicular lymphoma never nfkappabeta novo outline paired possessed rel tdlbcl transformation usp34
Tagcloud (Intersection) ?