OTX1 and PLA2G10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX1	PLA2G10
Description		orthodenticle homeobox 1	phospholipase A2 group X
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Cholesteryl ester levels ( 31551469)
Interacting Genes		148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34	55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		5013	8399
HPRD ID		08964	04674
Ensembl ID		ENSG00000115507	ENSG00000069764
Uniprot IDs		P32242	O15496
PDB IDs			1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus	Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin
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