OTX1 and CHRDL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX1	CHRDL2
Description		orthodenticle homeobox 1	chordin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding BMP Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development
Pathways
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		5013	25884
HPRD ID		08964	09881
Ensembl ID		ENSG00000115507	ENSG00000054938
Uniprot IDs		P32242	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process
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