NUMA1 and ERG

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NUMA1	ERG
Gene Name		nuclear mitotic apparatus protein 1	v-ets avian erythroblastosis virus E26 oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Nuclear Matrix Dendrite Neuronal Cell Body Apical Part Of Cell Extracellular Vesicular Exosome	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleus Organization Mitotic Nuclear Division Cell Division Meiotic Cell Cycle Lung Epithelial Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS			Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		22 interactors: ACTR1A BRAP CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ	61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2
Entrez ID		4926	2078
HPRD ID		01236	01298
Ensembl ID		ENSG00000137497	ENSG00000157554
Uniprot IDs		Q14980 Q3SYK8 Q4LE64	B4DN83 B4DVX5 P11308
PDB IDs		3RO2	1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Regulation Of Telomere Maintenance Cell Cycle Process Protein Localization To Chromosome, Telomeric Region Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cortical Actin Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Cortical Cytoskeleton Organization Cell Division Negative Regulation Of DNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Mitotic Nuclear Division Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cytoskeleton Organization Positive Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Mitotic Spindle Organization Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Organelle Organization Cell Dedifferentiation Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Cellular Response To Stimulus	MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly
Tagcloud ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?