NUMA1 and NCOA6

Number of citations of the paper that reports this interaction (PMID 12519782)
7

Data Source:
HPRD (in vitro)

		NUMA1	NCOA6
Gene Name		nuclear mitotic apparatus protein 1	nuclear receptor coactivator 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Nuclear Matrix Dendrite Neuronal Cell Body Apical Part Of Cell Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleus Organization Mitotic Nuclear Division Cell Division Meiotic Cell Cycle Lung Epithelial Cell Differentiation	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ACTR1A BRAP CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ	64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		4926	23054
HPRD ID		01236	05599
Ensembl ID		ENSG00000137497	ENSG00000198646
Uniprot IDs		Q14980 Q3SYK8 Q4LE64	F6M2K2 Q14686
PDB IDs		3RO2
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Regulation Of Telomere Maintenance Cell Cycle Process Protein Localization To Chromosome, Telomeric Region Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cortical Actin Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Cortical Cytoskeleton Organization Cell Division Negative Regulation Of DNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Mitotic Nuclear Division Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cytoskeleton Organization Positive Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Mitotic Spindle Organization Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Organelle Organization Cell Dedifferentiation Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Cellular Response To Stimulus	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Difference) ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Intersection) ?