NUMA1 and ACTR1A

Number of citations of the paper that reports this interaction (PMID 10504299)
10

Data Source:
HPRD (in vivo)

		NUMA1	ACTR1A
Gene Name		nuclear mitotic apparatus protein 1	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Nuclear Matrix Dendrite Neuronal Cell Body Apical Part Of Cell Extracellular Vesicular Exosome	Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Associated Complex Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleus Organization Mitotic Nuclear Division Cell Division Meiotic Cell Cycle Lung Epithelial Cell Differentiation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		22 interactors: ACTR1A BRAP CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ	6 interactors: ACTR10 DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		4926	10121
HPRD ID		01236	05507
Ensembl ID		ENSG00000137497	ENSG00000138107
Uniprot IDs		Q14980 Q3SYK8 Q4LE64	P61163
PDB IDs		3RO2
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Regulation Of Telomere Maintenance Cell Cycle Process Protein Localization To Chromosome, Telomeric Region Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cortical Actin Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Cortical Cytoskeleton Organization Cell Division Negative Regulation Of DNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Mitotic Nuclear Division Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cytoskeleton Organization Positive Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Mitotic Spindle Organization Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Organelle Organization Cell Dedifferentiation Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Cellular Response To Stimulus	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Actin Filament Capping Organelle Localization Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Mitotic Cell Cycle Process Negative Regulation Of Protein Complex Assembly Mitotic Cell Cycle Microtubule-based Process Establishment Of Localization In Cell Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Localization Common-partner SMAD Protein Phosphorylation Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition SMAD Protein Import Into Nucleus Microtubule-based Movement Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Cell Cycle Regulation Of Actin Cytoskeleton Organization Nuclear Migration Axon Guidance Vesicle-mediated Transport Regulation Of Actin Filament-based Process Cerebellar Purkinje Cell Layer Morphogenesis Cell Division Membrane Assembly Golgi To Plasma Membrane Protein Transport Regulation Of Cytoskeleton Organization Membrane Biogenesis Establishment Of Nucleus Localization Axonogenesis
Tagcloud ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?