NUMA1 and ABRAXAS2

Number of citations of the paper that reports this interaction (PubMedID 26195665)
52

Data Source:
BioGRID (pull down)

		NUMA1	ABRAXAS2
Description		nuclear mitotic apparatus protein 1	abraxas 2, BRISC complex subunit
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cell Cortex Membrane Lateral Plasma Membrane Nuclear Matrix Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Midbody Spindle Pole Centrosome Ciliary Basal Body Microtubule Minus-end BRISC Complex
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding Lipid Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly
Pathways		Recruitment of NuMA to mitotic centrosomes Mitotic Prophase	Metalloprotease DUBs
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Bone mineral content ( 31790847)
Interacting Genes		26 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 RNF10 SMC1A SUMO2 TERF1 TERF2 TNKS USP7 YEATS4 YWHAQ	7 interacting genes: DCUN1D1 NUMA1 OGT SMURF2 THAP5 UBC USP7
Entrez ID		4926	23172
HPRD ID		01236	13783
Ensembl ID		ENSG00000137497	ENSG00000165660
Uniprot IDs		Q14980 Q3SYK8	Q15018
PDB IDs		3RO2 5GXW 6HC2 6QJA	6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		Cell Division Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeleton Regulation Of Cell Cycle Spindle Pole Mitotic Spindle Pole Regulation Of Cell Cycle Process Regulation Of Telomere Capping Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Protein Localization To Cell Periphery Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cell Cortex Nucleoplasm Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cortical Actin Cytoskeleton Organization Mitotic Spindle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Cohesin Complex Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex BRISC Complex Regulation Of Mitotic Spindle Organization Positive Regulation Of Metabolic Process Centrosome Cortical Cytoskeleton Organization Regulation Of Organelle Organization Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Nuclear Matrix Mitotic Cohesin Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Cell Cycle Process Establishment Of Sister Chromatid Cohesion Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding	Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Protein Ubiquitination Cortical Microtubule Anastral Spindle Assembly Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Nucleus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Mitotic Spindle Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Arginyl-tRNA--protein Transferase Activity Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Protein Localization To Vacuole Lateral Cell Cortex Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Protein Arginylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway Cell Cortex Region Regulation Of Cellular Localization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Mitotic Spindle Astral Microtubule Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Microtubule Bundle Regulation Of Protein Localization To Cell Periphery Regulation Of TOR Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Ubiquitin-like Protein Binding
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