NUMA1 and GPSM2

Number of citations of the paper that reports this interaction (PMID 11781568)
71

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		NUMA1	GPSM2
Gene Name		nuclear mitotic apparatus protein 1	G-protein signaling modulator 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Nuclear Matrix Dendrite Neuronal Cell Body Apical Part Of Cell Extracellular Vesicular Exosome	Cytoplasm Cell Cortex Apical Part Of Cell
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	Protein Binding GTPase Regulator Activity Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleus Organization Mitotic Nuclear Division Cell Division Meiotic Cell Cycle Lung Epithelial Cell Differentiation	Establishment Of Mitotic Spindle Orientation G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Lung Epithelial Cell Differentiation
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS			Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		22 interactors: ACTR1A BRAP CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ	8 interactors: GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC NUMA1
Entrez ID		4926	29899
HPRD ID		01236	06609
Ensembl ID		ENSG00000137497	ENSG00000121957
Uniprot IDs		Q14980 Q3SYK8 Q4LE64	P81274
PDB IDs		3RO2	3SF4
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Regulation Of Telomere Maintenance Cell Cycle Process Protein Localization To Chromosome, Telomeric Region Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cortical Actin Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Cortical Cytoskeleton Organization Cell Division Negative Regulation Of DNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Mitotic Nuclear Division Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cytoskeleton Organization Positive Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Mitotic Spindle Organization Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Organelle Organization Cell Dedifferentiation Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Cellular Response To Stimulus	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Cycle Blood Coagulation Cell Division Hemostasis Negative Regulation Of Adenylate Cyclase Activity Regulation Of Body Fluid Levels Synaptic Transmission Negative Regulation Of Lyase Activity Wound Healing Platelet Activation Establishment Of Mitotic Spindle Orientation Negative Regulation Of CAMP Biosynthetic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of CAMP Metabolic Process Response To Wounding Lung Development Respiratory Tube Development Negative Regulation Of Nucleotide Metabolic Process Respiratory System Development Spindle Localization Lung Epithelial Cell Differentiation Lung Cell Differentiation Vesicle Fusion Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Lung Epithelium Development Activation Of MAPKK Activity Regulation Of Cyclase Activity Organelle Fusion G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Establishment Of Cell Polarity Regulation Of CAMP Metabolic Process Membrane Fusion Mitotic Cell Cycle Process Cell Activation Tube Development Establishment Or Maintenance Of Cell Polarity Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Organelle Organization Positive Regulation Of Rac Protein Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Catalytic Activity Positive Regulation Of MiRNA Metabolic Process Response To Organonitrogen Compound
Tagcloud ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	camk1 centriole dkk1 enah endosome geo inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose	camk1 centriole dkk1 enah endosome geo inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?