NOTCH2 and PSEN2

Number of citations of the paper that reports this interaction (PubMedID 11518718)
0

Data Source:
HPRD (in vivo)

		NOTCH2	PSEN2
Description		notch receptor 2	presenilin 2
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane
	Molecular Function	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation
Drugs
Diseases		Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus	Alzheimer's disease (AD)
GWAS		Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34012112 34127860) Type 2 diabetes ( 18372903 30054458 30297969)	Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1	61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1
Entrez ID		4853	5664
HPRD ID		02606	02860
Ensembl ID		ENSG00000134250	ENSG00000143801
Uniprot IDs		Q04721 Q6IQ50	P49810
PDB IDs		2OO4 5MWB	7Y5X 7Y5Z
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis	Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation
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