NOTCH2 and EGFL7

Number of citations of the paper that reports this interaction (PMID 19503073)
23

Data Source:
BioGRID (two hybrid)

		NOTCH2	EGFL7
Gene Name		notch 2	EGF-like-domain, multiple 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity	Notch Binding Calcium Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion	Angiogenesis Blood Vessel Development Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Notch Signaling Pathway
Pathways		Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Type 2 diabetes ( 18372903)
Protein-Protein Interactions		18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1	6 interactors: GFI1B NOTCH1 NOTCH2 NOTCH3 NOTCH4 SMARCD1
Entrez ID		4853	51162
HPRD ID		02606	16351
Ensembl ID		ENSG00000134250	ENSG00000172889
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q9UHF1
PDB IDs		2OO4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis	Notch Receptor Processing Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Fate Commitment Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Blood Vessel Development Vasculature Development Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Negative Regulation Of Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Cardiovascular System Development Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis System Development Heart Valve Development Positive Regulation Of BMP Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Angiogenesis RNA Biosynthetic Process Multicellular Organismal Development Cell Fate Determination Regulation Of Gene Expression Anatomical Structure Development Cardiac Septum Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Glomerulus Development Morphogenesis Of An Epithelial Sheet Blood Vessel Morphogenesis Pattern Specification Process Endothelial Cell Differentiation Developmental Process Neuron Fate Commitment Cardiac Septum Development Organ Development Regulation Of BMP Signaling Pathway Morphogenesis Of An Epithelium Endothelium Development
Tagcloud ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	coculture consistently controlling crosstalk differentiation dissect embryonic endocrine endothelial endothelium epithelium handle hesc impair maintain mechanistic organogenesis pancreatic paradigm pp precise progenitor progenitors renewal signals stepwise toward transgenic unclear
Tagcloud (Difference) ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	coculture consistently controlling crosstalk differentiation dissect embryonic endocrine endothelial endothelium epithelium handle hesc impair maintain mechanistic organogenesis pancreatic paradigm pp precise progenitor progenitors renewal signals stepwise toward transgenic unclear
Tagcloud (Intersection) ?