NOTCH2 and DTX1

Number of citations of the paper that reports this interaction (PMID 9244302)
102

Data Source:
HPRD (in vivo)

		NOTCH2	DTX1
Gene Name		notch 2	deltex 1, E3 ubiquitin ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion	Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Nucleic Acid-templated Transcription
Pathways		Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Type 2 diabetes ( 18372903)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1	20 interactors: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U
Entrez ID		4853	1840
HPRD ID		02606	03991
Ensembl ID		ENSG00000134250	ENSG00000135144
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q86Y01
PDB IDs		2OO4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis	Protein K48-linked Ubiquitination Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Notch Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response Activation Of Innate Immune Response Defense Response Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Histone Ubiquitination Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Immune System Process Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity Positive Regulation Of Immune Response Signal Transduction Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Signaling Proteasomal Protein Catabolic Process Cell Communication Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint
Tagcloud ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Difference) ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Intersection) ?