NOTCH2 and DLL1

Number of citations of the paper that reports this interaction (PMID 10958687)
30

Data Source:
HPRD (in vivo)

		NOTCH2	DLL1
Gene Name		notch 2	delta-like 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion	Cell Fate Determination Somite Specification Heart Looping Notch Signaling Pathway Notch Receptor Processing Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Interleukin-10 Production Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Left/right Axis Specification Proximal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance
Pathways		Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus	Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Type 2 diabetes ( 18372903)	Type 1 diabetes ( 21980299)
Protein-Protein Interactions		18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1	10 interactors: ADAM10 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 NOV POFUT1 PSEN1
Entrez ID		4853	28514
HPRD ID		02606	05957
Ensembl ID		ENSG00000134250	ENSG00000198719
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	O00548
PDB IDs		2OO4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis	Notch Receptor Processing Notch Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Pattern Specification Process Blood Vessel Development Vasculature Development Epithelium Development Glomerulus Development Cell Surface Receptor Signaling Pathway Cell Fate Commitment Multicellular Organismal Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Interleukin-4 Production Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Generation Of Neurons Cardiovascular System Development Developmental Process Neurogenesis Membrane Protein Ectodomain Proteolysis Tissue Development Nephron Development System Development Cell Development Embryonic Limb Morphogenesis Myeloid Dendritic Cell Differentiation Glomerulus Vasculature Development Morphogenesis Of An Epithelium Heart Development Transcription Initiation From RNA Polymerase II Promoter Organ Development Myeloid Dendritic Cell Activation Neuron Differentiation Limb Morphogenesis Regulation Of Neuron Differentiation Embryo Development Negative Regulation Of Neuron Differentiation Limb Development Regulation Of Cell Migration Membrane Protein Proteolysis Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Morphogenesis Regulation Of Cell Motility
Tagcloud ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Difference) ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Intersection) ?		notch notch1