NOTCH2

Name	notch receptor 2
Structure
Novel Interactors	2 novel interactors: PTPN22 WDR5
Interactors	31 interactors: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development
Pathways	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Diseases	Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus
GWAS	Blood protein levels ( 30072576 ) Hepatocyte growth factor levels ( 25998175 ) Nevus count or cutaneous melanoma ( 32341527 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 34012112 34127860 ) Type 2 diabetes ( 18372903 30054458 30297969 )
Entrez ID	4853
HPRD ID	02606
Ensembl ID	ENSG00000134250
Uniprot IDs	Q04721 Q6IQ50
PDB IDs	2OO4 5MWB
GO Terms Enriched among Interactors ?	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis