NOTCH2 and RBPJ

Number of citations of the paper that reports this interaction (PMID 9032325)
32

Data Source:
HPRD (in vivo, in vitro)

		NOTCH2	RBPJ
Gene Name		notch 2	recombination signal binding protein for immunoglobulin kappa J region
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity	Recombinase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation DNA Recombination Transcription Initiation From RNA Polymerase II Promoter Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Gene Expression Pituitary Gland Development B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Timing Of Cell Differentiation Sebaceous Gland Development Hair Follicle Maturation Positive Regulation Of Cardiac Muscle Cell Proliferation Clara Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Notch Signaling Involved In Heart Development Blood Vessel Lumenization Interleukin-4 Secretion Blood Vessel Endothelial Cell Fate Specification Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Type 2 diabetes ( 18372903)	Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1	24 interactors: APP CIR1 FHL1 GADD45A GSK3B HDAC1 HMGB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A RPS6KA6 SIN3A SND1 SNW1 SPEN SUFU
Entrez ID		4853	3516
HPRD ID		02606	00920
Ensembl ID		ENSG00000134250	ENSG00000168214
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q06330
PDB IDs		2OO4	2F8X 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis	Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Developmental Process Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated System Development Anatomical Structure Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nervous System Development Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Cell Differentiation Organ Development Central Nervous System Development Negative Regulation Of Cell Differentiation Regulation Of Cellular Process Positive Regulation Of Metabolic Process
Tagcloud ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch numb numbl oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jun physically ras rbp reversed rpb sapk unaffected	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating mechanistically modulator nicd numb numbl oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?		jkappa notch