NOTCH2 and JAG2

Number of citations of the paper that reports this interaction (PMID 10958687)
30

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NOTCH2	JAG2
Gene Name		notch 2	jagged 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion	Skeletal System Development In Utero Embryonic Development Respiratory System Process Cell Cycle Notch Signaling Pathway Notch Receptor Processing Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Migration Regulation Of Cell Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Pathways		Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus	Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Type 2 diabetes ( 18372903)
Protein-Protein Interactions		18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1	8 interactors: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3
Entrez ID		4853	3714
HPRD ID		02606	03981
Ensembl ID		ENSG00000134250	ENSG00000184916
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q9Y219
PDB IDs		2OO4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis	Notch Receptor Processing Notch Signaling Pathway Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription, DNA-templated Glomerulus Vasculature Development RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cardiac Septum Morphogenesis Regulation Of Calcium Ion-dependent Exocytosis Central Nervous System Development Glomerulus Development Morphogenesis Of An Epithelial Sheet Cell Differentiation In Spinal Cord Gene Expression Cell Death Death Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Cardiac Septum Development Regulation Of BMP Signaling Pathway Cerebellar Molecular Layer Development Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Nervous System Development Growth Secretion By Cell Blood Vessel Development Negative Regulation Of Gene Expression
Tagcloud ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	bisulfite cerebellum dll1 enrichment enzymatic epigenetics homeostasis hydroxymethylation hydroxymethylcytosine hypomethylation intercellular intergenic intragenic myoblasts myofibers myotubes nonmuscle notch notch1 notch2 poised precisely renewal representation rrbs skeletal spatially temporally unusually
Tagcloud (Difference) ?		activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected	bisulfite cerebellum dll1 enrichment enzymatic epigenetics homeostasis hydroxymethylation hydroxymethylcytosine hypomethylation intercellular intergenic intragenic myoblasts myofibers myotubes nonmuscle poised precisely renewal representation rrbs skeletal spatially temporally unusually
Tagcloud (Intersection) ?		notch notch1 notch2