LINGO1 and KRTAP4-12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LINGO1	KRTAP4-12
Gene Name		leucine rich repeat and Ig domain containing 1	keratin associated protein 4-12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Keratin Filament
	Molecular Function	Epidermal Growth Factor Receptor Binding	Protein Binding
	Biological Process	Central Nervous System Neuron Development Neuron Projection Development Protein Kinase B Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Essential tremor ( 19182806)
Protein-Protein Interactions		8 interactors: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27	107 interactors: ADAMTSL4 ALPP AQP1 ATG12 ATN1 BAHD1 BEX2 C10orf62 C19orf66 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CHCHD3 CHIC2 CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 DBF4B DLK2 EIF4E2 FAM107A FAM27E3 FAM76B FBXL18 FBXW5 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 ILF3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP3-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2D LCE3E LCE4A LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NL NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP PRKAB2 PRR13 QPRT RERE RPS28 SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY2 TAP1 TBC1D16 TBC1D23 TCEB3B THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF581 ZNF638 ZNF655 ZNF764 ZSCAN26
Entrez ID		84894	83755
HPRD ID		14322	13941
Ensembl ID		ENSG00000169783	ENSG00000213416
Uniprot IDs		Q96FE5	Q9BQ66
PDB IDs		2ID5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cell Projection Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Regulation Of Axonogenesis Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization Regulation Of Organ Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Calcium Ion Import Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Chromosome Segregation Positive Regulation Of Oxidative Stress-induced Cell Death Interferon-gamma Secretion Regulation Of DNA Endoreduplication Negative Regulation Of Neurogenesis Regulation Of Hepatocyte Proliferation Positive Regulation Of Odontogenesis Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Development Negative Regulation Of Viral Release From Host Cell Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Neuron Projection Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Cell Cycle Regulation Of Triglyceride Biosynthetic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Cell Cycle	Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Keratinization Anterior/posterior Pattern Specification Regulation Of Cellular Process Regulation Of Metabolic Process Cellular Process Keratinocyte Differentiation Embryo Development Phospholipid Scrambling Metanephric Glomerulus Vasculature Development Pattern Specification Process Metanephric Glomerulus Development Epidermal Cell Differentiation Epidermis Development Mitochondrion Organization Metabolic Process Forebrain Morphogenesis Transcription From RNA Polymerase II Promoter Glomerulus Vasculature Development Multicellular Organismal Development Organic Anion Transport Inner Ear Development Cell Migration Involved In Coronary Angiogenesis Hepatic Duct Development Abducens Nerve Formation Metanephric Mesenchymal Cell Migration Transepithelial Water Transport Renin Secretion Into Blood Stream Metanephric Descending Thin Limb Development DGDP Catabolic Process Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development
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