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LINGO1
Gene Name
leucine rich repeat and Ig domain containing 1
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Epidermal Growth Factor Receptor Binding
Biological Process
Central Nervous System Neuron Development
Neuron Projection Development
Protein Kinase B Signaling
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Oligodendrocyte Differentiation
Regulation Of Axonogenesis
Negative Regulation Of Axonogenesis
Pathways
Signalling by NGF
Axonal growth inhibition (RHOA activation)
p75NTR regulates axonogenesis
p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Essential tremor (
19182806
)
Protein-protein Interactions
8 interactors:
EFEMP2
FBXW7
GOLGA2
KRTAP4-12
NGFR
RTN4R
SPAG5
TRIM27
Entrez ID
84894
HPRD ID
14322
Ensembl ID
ENSG00000169783
Uniprot IDs
Q96FE5
PDB IDs
2ID5
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Axonogenesis
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Cell Morphogenesis Involved In Differentiation
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Triglyceride Biosynthetic Process
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Cell Projection Organization
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hair Follicle Development
Regulation Of Axonogenesis
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of Hair Cycle
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Regulation Of Protein Localization
Regulation Of Organ Morphogenesis
Regulation Of Cellular Component Organization
Negative Regulation Of Neuron Differentiation
Negative Regulation Of DNA Endoreduplication
Positive Regulation Of Apoptotic Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Calcium Ion Import
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Neurotrophin Signaling Pathway
Chromosome Segregation
Positive Regulation Of Oxidative Stress-induced Cell Death
Interferon-gamma Secretion
Regulation Of DNA Endoreduplication
Negative Regulation Of Neurogenesis
Regulation Of Hepatocyte Proliferation
Positive Regulation Of Odontogenesis
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Development
Negative Regulation Of Viral Release From Host Cell
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Odontogenesis Of Dentin-containing Tooth
Regulation Of Neuron Projection Development
Membrane Protein Intracellular Domain Proteolysis
Regulation Of Hair Follicle Development
Cell Cycle
Regulation Of Triglyceride Biosynthetic Process
Interferon-gamma Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Glucose Import In Response To Insulin Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Viral Transcription
Regulation Of Hair Cycle
Regulation Of Viral Release From Host Cell
Regulation Of Calcium Ion Import
Negative Regulation Of Cell Cycle
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