LINGO1 and EFEMP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LINGO1	EFEMP2
Gene Name		leucine rich repeat and Ig domain containing 1	EGF containing fibulin-like extracellular matrix protein 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Basement Membrane Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding	Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Central Nervous System Neuron Development Neuron Projection Development Protein Kinase B Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	Signal Transduction Blood Coagulation Extracellular Matrix Organization
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Essential tremor ( 19182806)
Protein-Protein Interactions		8 interactors: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27	50 interactors: APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		84894	30008
HPRD ID		14322	05221
Ensembl ID		ENSG00000169783	ENSG00000172638
Uniprot IDs		Q96FE5	O95967 Q9H3D5
PDB IDs		2ID5	2KL7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cell Projection Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Regulation Of Axonogenesis Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization Regulation Of Organ Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Calcium Ion Import Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Chromosome Segregation Positive Regulation Of Oxidative Stress-induced Cell Death Interferon-gamma Secretion Regulation Of DNA Endoreduplication Negative Regulation Of Neurogenesis Regulation Of Hepatocyte Proliferation Positive Regulation Of Odontogenesis Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Development Negative Regulation Of Viral Release From Host Cell Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Neuron Projection Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Cell Cycle Regulation Of Triglyceride Biosynthetic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Cell Cycle	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Response To Salt Stress Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process System Development Developmental Process Phospholipid Scrambling Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Heart Contraction Neuron Death Pons Development Anatomical Structure Development Central Nervous System Development Positive Regulation Of Gene Expression Blood Vessel Development Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?			acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?			acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?