LINGO1 and RTN4R

Number of citations of the paper that reports this interaction (PMID 14966521)
127

Data Source:
HPRD (in vitro, in vivo)

		LINGO1	RTN4R
Gene Name		leucine rich repeat and Ig domain containing 1	reticulon 4 receptor
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Cell Surface Growth Cone Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding	Receptor Activity Protein Binding
	Biological Process	Central Nervous System Neuron Development Neuron Projection Development Protein Kinase B Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling	Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Essential tremor ( 19182806)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27	6 interactors: LINGO1 MAG NGFR OMG RTN4 RTN4IP1
Entrez ID		84894	65078
HPRD ID		14322	16123
Ensembl ID		ENSG00000169783	ENSG00000040608
Uniprot IDs		Q96FE5	Q9BZR6
PDB IDs		2ID5	1OZN 1P8T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cell Projection Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Regulation Of Axonogenesis Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization Regulation Of Organ Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Calcium Ion Import Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Chromosome Segregation Positive Regulation Of Oxidative Stress-induced Cell Death Interferon-gamma Secretion Regulation Of DNA Endoreduplication Negative Regulation Of Neurogenesis Regulation Of Hepatocyte Proliferation Positive Regulation Of Odontogenesis Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Development Negative Regulation Of Viral Release From Host Cell Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Neuron Projection Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Cell Cycle Regulation Of Triglyceride Biosynthetic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Cell Cycle	Negative Regulation Of Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Negative Regulation Of Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Neurogenesis Negative Regulation Of Cell Development Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Cell Differentiation Regulation Of Cell Development Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Regulation Of Cell Differentiation Neurogenesis Cellular Response To Organic Substance Neuron Projection Development Regulation Of Cellular Component Organization Neuron Development Central Nervous System Development Nervous System Development Neuron Differentiation Response To Organic Substance Cell Projection Organization Cell Surface Receptor Signaling Pathway Cell Differentiation Cell Development Regulation Of Cell Size Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Hair Follicle Development Regulation Of Branching Morphogenesis Of A Nerve System Development Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Hair Cycle Multicellular Organismal Development Endoplasmic Reticulum Tubular Network Organization Anatomical Structure Development Regulation Of Developmental Growth Signal Transduction Locomotion Positive Regulation Of Odontogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?