LINGO1 and SPAG5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LINGO1	SPAG5
Gene Name		leucine rich repeat and Ig domain containing 1	sperm associated antigen 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Mitotic Spindle
	Molecular Function	Epidermal Growth Factor Receptor Binding	Protein Binding
	Biological Process	Central Nervous System Neuron Development Neuron Projection Development Protein Kinase B Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Essential tremor ( 19182806)
Protein-Protein Interactions		8 interactors: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27	35 interactors: AMOTL2 ARNT2 ATN1 BARD1 C1orf109 CCDC33 CCHCR1 CDC20B CDK1 CHCHD3 DCX EIF4E2 EIF4ENIF1 FBXO28 FMR1 GOLGA8EP GOLGA8F HAUS1 IQCE KANSL1 LGALS14 LINGO1 ODF1 ORC6 POLR2L RBM41 SH2D4A SMARCE1 SNAP47 SNAPIN TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZMAT2
Entrez ID		84894	10615
HPRD ID		14322	10246
Ensembl ID		ENSG00000169783	ENSG00000076382
Uniprot IDs		Q96FE5	Q96R06
PDB IDs		2ID5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cell Projection Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Regulation Of Axonogenesis Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization Regulation Of Organ Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Calcium Ion Import Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Chromosome Segregation Positive Regulation Of Oxidative Stress-induced Cell Death Interferon-gamma Secretion Regulation Of DNA Endoreduplication Negative Regulation Of Neurogenesis Regulation Of Hepatocyte Proliferation Positive Regulation Of Odontogenesis Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Development Negative Regulation Of Viral Release From Host Cell Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Neuron Projection Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Cell Cycle Regulation Of Triglyceride Biosynthetic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Cell Cycle	Organelle Fusion Negative Regulation Of Gene Expression Synaptic Vesicle Fusion To Presynaptic Membrane Membrane Fusion Negative Regulation Of Cellular Metabolic Process Developmental Process Multicellular Organismal Development Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Positive Regulation Of Late Endosome To Lysosome Transport Pronuclear Fusion Nervous System Development Vesicle Fusion Synaptic Vesicle Exocytosis Negative Regulation Of Biosynthetic Process Negative Regulation Of MRNA 3'-end Processing Central Nervous System Development Regulation Of Glial Cell Differentiation Terminal Button Organization Autophagic Vacuole Maturation Negative Regulation Of Translation
Tagcloud ?			aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst exosc3 hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b synapt tryptic unsupervised urgent
Tagcloud (Difference) ?			aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst exosc3 hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b synapt tryptic unsupervised urgent
Tagcloud (Intersection) ?